3D Printing Body Parts
Cornell researchers bioengineer 3D printed ears that look and act like the real thing.
Cornell bioengineers and physicians have created an artificial ear – using 3D printing and injectable molds – that looks and acts like a natural ear.
In a study published online Feb. 20 in PLOS ONE, Cornell biomedical engineers and Weill Cornell Medical College physicians described how 3D printing and injectable gels made of living cells can fashion ears that are practically identical to a human ear. Over a three-month period, these flexible ears grew cartilage to replace the collagen that was used to mold them.
To make the ears, Bonassar and colleagues started with a digitized 3D image of a human subject’s ear, and converted the image into a digitized “solid” ear using a 3D printer to assemble a mold.
This Cornell-developed, high-density gel is similar to the consistency of Jell-o when the mold is removed. The collagen served as a scaffold upon which cartilage could grow.
The process is also fast, Bonassar added: “It takes half a day to design the mold, a day or so to print it, 30 minutes to inject the gel, and we can remove the ear 15 minutes later. We trim the ear and then let it culture for several days in nourishing cell culture media before it is implanted.”
The novel ear may be the solution reconstructive surgeons have long wished for to help children born with ear deformity, said co-lead author Dr. Jason Spector, director of the Laboratory for Bioregenerative Medicine and Surgery and associate professor of plastic surgery at Weill Cornell in New York City.
“A bioengineered ear replacement like this would also help individuals who have lost part or all of their external ear in an accident or from cancer,” Spector said.
Replacement ears are usually constructed with materials that have a Styrofoam-like consistency, or sometimes, surgeons build ears from a patient’s harvested rib. This option is challenging and painful for children, and the ears rarely look completely natural or perform well, Spector said.
Spector and Bonassae have been collaborating on bioengineered human replacement parts since 2007. Bonassar has also worked with Weill Cornell neurological surgeon Dr. Roger Härtl on bioengineered disc replacements using some of the same techniques demonstrated in the PLOS
The researchers specifically work on replacement human structures that are primarily made of cartilage – joints, trachea, spine, nose – because cartilage does not need to be vascularized with a blood supply in order to survive.
If all future safety and efficacy tests work out, it might be possible to try the first human implant of a Cornell bioengineered ear in as little as three years, Spector said.